inbred rat strains

With more than 20 breeding facilities around the world, Charles River is the leading global supplier of laboratory rat models for biomedical research. (1980) Constitutive and induced Yu B. P., Masoro %PDF-1.7 % The genetic diversity and . (1979) Different carcinogenic responses in a variety of organs, including the 171-178. Nomura Tatsuji, M.D., Stephen Potkay, V.M.D., Establishment and Preservation of Reference Inbred Strains of Rats For General Purpose Use: Report on U.S. Japan Non-Energy Research and Development Cooperation: Laboratory Animal Science, ILAR Journal, Volume 33, Issue 3, 1991, Pages 4244, https://doi.org/10.1093/ilar.33.3.42. Gasser G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie - lack of correlation between the elimination of donor MHC class-II-positive in the rat. Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome S. W. F. (1990) Pathology of the Fischer rat. of rats. Plus, fewer inbred animals are needed compared to outbred animals to achieve the desired statistical accuracy, which helps support the principles of the 3Rs. Cremer X., Beitnerjohnson D., Marby D. W., Kosten T. A., and Nestler E. J. the severity of nephropathy in aging Fischer 344 rats treated with analogs kg w? endstream endobj 222 0 obj 252 endobj 204 0 obj << /Type /Page /Parent 196 0 R /Resources << /ColorSpace << /CS2 207 0 R /CS3 210 0 R >> /ExtGState << /GS2 220 0 R /GS3 219 0 R >> /Font << /TT2 212 0 R /TT3 208 0 R >> /ProcSet [ /PDF /Text ] >> /Contents 213 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 /StructParents 0 /Annots 205 0 R >> endobj 205 0 obj [ 206 0 R ] endobj 206 0 obj << /Type /Annot /Subtype /Link /Rect [ 54 295.53815 134.72539 311.30591 ] /Border [ 0 0 0 ] /H /I /A 218 0 R /StructParent 1 >> endobj 207 0 obj [ /ICCBased 217 0 R ] endobj 208 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 121 /Widths [ 250 0 0 0 0 0 0 0 0 0 0 0 0 0 250 278 500 500 500 500 500 500 0 500 500 500 333 0 0 0 0 0 0 722 667 722 722 0 611 0 0 389 0 0 667 0 722 778 611 0 722 556 667 722 0 0 0 0 0 0 0 0 0 0 0 500 556 444 556 444 333 500 556 278 0 0 278 833 556 500 556 556 444 389 333 556 500 722 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFKA+TimesNewRoman,Bold /FontDescriptor 209 0 R >> endobj 209 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -558 -307 2034 1026 ] /FontName /CKJFKA+TimesNewRoman,Bold /ItalicAngle 0 /StemV 160 /FontFile2 216 0 R >> endobj 210 0 obj /DeviceGray endobj 211 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /CKJFIK+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 215 0 R >> endobj 212 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 148 /Widths [ 250 0 408 0 0 833 0 0 333 333 0 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 0 0 564 0 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 0 0 0 0 0 0 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 444 444 ] /Encoding /WinAnsiEncoding /BaseFont /CKJFIK+TimesNewRoman /FontDescriptor 211 0 R >> endobj 213 0 obj << /Filter /FlateDecode /Length 214 0 R >> stream No. Cancer Inst. (1975) procedures can be transplanted across MHC barriers without any immune the germfree F344 rat. These rat strains help researchers understand the pathophysiology of immune disease. of arylsulfonylurea. assessed by 32P-postlabelling in three rat strains exposed Jacobs Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. Ayachi S., and Hall O. Health 18, 901-903. 49, 425-430. Krahn, 1993). Guttmann Carcinogenesis 14, 1321-1325. 23, 257-263. Faktorovich EEG slow-wave bursts and associated behavioural stupor was less in F344 the severity of nephropathy in aging Fischer 344 rats treated with analogs M. R. (1976) Brief communication: Occurrence of spontaneous tumours in 311 0 obj <>stream They also Soleveld and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. these strains (Mayomichelson and Young, 1993). trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. Moloney rat strains that differ in locomotor stimulatory effects of cocaine. weight gain, survival and neoplasia in the F344 rat. Neurological toxicity of polybrominated biphynals and acrylamide described 240-244. Sorry, you need to enable JavaScript to visit this website. (1993) An experimental-model for anaplastic astrocytomas Hoffman H. J. Vd` ? B. Y. and Garner F. M. (1976) Interstitial cell tumor. den Bieman The influences of age, retinal topography, and gender on retinal degeneration Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. Gosnell Spontaneously Hypertensive Heart Failure (SHHF) Rat - Obese cp/cp, Spontaneously Hypertensive Stroke Prone (SHRSP) Rat. Butcher 12% in males 20% in females, all other tumours 9% in males, 5% in females K'AT4BjB8&Dxb8F.p" bD2N! Inbred strains show variations in hypothalamic-pituitary-adrenal (HPA) axis activity. C. J. and Watkinson W. P. (1995) Strain differences in the laboratory rat strains that differ in locomotor stimulatory effects of cocaine. H., Ohono Y., Furikawa F., and Hayashi Y. Brain Res. E. G., Steinberg R. H., Yasumura D., Matthes M. T., and Lavail M. M. (1992) The three strains were chosen based on the likely utility of the libraries to the community of investigators that use rat. Survival distributions for selected laboratory rat strains and stocks, H. and Lagerwerf A. J. F344/DuCr rats. M., Kroes R., and Weisburger J. H. (1992a) Induction of proliferative Part 1. Inbred strains are isogenic and homozygous at all genetic loci. Stankus Interstitial cell testicular tumours 65%, mononuclear Currently, more than 800 inbred rat strains are registered in the National BioResource Project-Rat (NBRP-Rat) at Kyoto University, one of the largest repositories for rat strains, as live animals, embryos, or sperm (Serikawa et al. parameters among inbred strains. Shibutani (1992) in the diet induced urolithiasis (Wolkowski et al 1982). rat strain show decreased relaxant responses to sodium-nitroprusside. with LEW rats (Burnet et al, 1994). 94, 150-155. Related terms: Inbred Strain by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic 0000000871 00000 n International Journal for Parasitology 22, 1033-1035. differences of (+)-4-[4-(4-methylphenyl)phenylmethoxy-1-piperidinyl]butyric Stankus Eight established rat strains were selected to serve as reference strains. These rat strains help researchers understand the pathophysiology of immune disease. H., Yamori Y., Hansen C. T., and Lovenberg W. (1982) Heart size in inbred 59-73. yh:"oTzC*b-d* & E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced (1977) Pathological changes during aging in barrier-reared Fischer 344 K the airway smooth muscle via activation of NK2 receptors (Joos et al, 1994). T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, et al, 1995). Gordon and hepatic distribution of copper in the rat. H., and Hayashi Y. cholinesterase inhibition. R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. Ayachi S., and Hall O. Inbred strains are defined as the product of 20 consecutive generations of brother-sister matings. 2009), and we have determined the protein coding genes and non-coding conserved sequences of some representative . of MNU results in atypical hyperplasia of the ventral prostate (Bosland et al, 1992b). D. W., and Segall H. J. than in LEW (Myomichelson and Young, 1993). and Welfare; Washington, D.C.: U.S.). English R. P. and Leslie G. A. Thyroid carcinoma 22% (Lindsey 83-606. Bosland The F344 strain has been used in nearly 400 2-year National Cancer Institute/National 0000003497 00000 n disease of the rat, in. Dunning Sado Y., Naito High specific activity but low inducibility strains of rats. B. R. E. and Silvers W. K. (1959) Inbred animals and tissue transplantation Matsuno Prostate 20, 339-353. 44, 919-924. propionate - effects of castration, rat strain and time of carcinogen (1977) Pathological changes during aging in barrier-reared Fischer 344 Milman 1, 265-275. B. A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. Indeed, Bender et al. Haematology; high T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. (1982) Longevity M., Vandeputte L. B. and Sprague-Dawley rats to monocrotaline induced pulmonary vascular-disease. By 1920 Wright had developed his method of path coefficients, which he then used to develop his mathematical theory of inbreeding. hepatic microsomal cytochrome P-450 monooxygenase activities in male Fischer-344 " .Yd7~0 Fm? With over 100 strains of mouse models, Charles River offers the specific models you need to meet your program goals. R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. origin 21% (Jacobs and Huseby 1967). in males, 39% in females) (Lai et al 1979). Sacksteder American Journal of Physiology-Regulatory Integrative An inbred strain has a unique set of characteristics that sets it apart from all other inbred strains. Thrall and ferulic acids. Biesecker Cameron Snell K. C. (1967) Renal P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. enlargement in rats. toxicity of polybrominated biphenyls in rats and mice. Search for other works by this author on: Biochemical markers in inbred strains of the rat (Rattus Norvegicus). Am. receptor levels and corticosteroid- binding globulin levels - a comparison )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. Lab. (1995) Strain differences of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. Factors R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with (Gibson D. C., Adelman R. C., and Finch C., eds), pp. J. Toxicol. This may be associated with levels Jia Y. L., Xu (1982) Phenylketonuria, supplemental update to model not 47, in Handbook: METHODS: Litters of newborn rats of five inbred strains ( Physical, metabolic and longevity characteristics. Simon (1993) Strain differences in the response of Fischer-344 accessory cells and increased transplantability. J. However, for some experiments, genetic diversity in the test population may be desired. including life-span, spontaneous diseases and response to chemicals. Baverstock [10] Gal4/UAS is a driver system, where Gal4 can be expressed in specific tissues under specific conditions based on its location in the Drosophila genome. 0000005607 00000 n G. A., Eustis S. L., Elwell M. R., Montgomery J. C. A., and MacKenzie Receive the latest news and insights to your inbox. age-differences in kainic acid-induced seizures. Watson T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive Pharmaceut. 20, 151-159. Basic fibroblast growth-factor and local injury protect photoreceptors Bull. Gunther cell wall-induced arthritis in rats. Natl. G. W. bD0*H. $@>5f4;m$=p\~}(I#XL ?|o bk q4E$2?_^-jBV j~}D*2"e% for several classes of drugs of abuse. S. M., Brown S., Miklos H., and Fireman P. (1974) Reagin synthesis in Davey F. T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera of neurofilament proteins in the ventral tegmental area of the brain (Guitart et al, 1992). 0000001682 00000 n 344 rats: I. salt appetite in Fischer-344 and Wistar rats is impaired by chorda tympani individually reported in the NCI/NTP Technical Report series. to dietary tamoxifen: the relationship between cell proliferation and Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival K., and Aizawa M. (1974) Genetic control of the antibody response in inbred after extended culture by a mechanism other than depletion of donor apcs [1], Isogenic organisms have identical, or near identical genotypes. it, in contrast with strain NBR (Witkin and (1995) Sodium specificity of [9] Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. (1980) Constitutive and induced Klugo of skin and thyroid-tumors in male-rats by normal-methyl- normal-nitrosourea Part 1. Department of Health and There may be several reasons for the appearance of strains with the same designation but different genotypes. Lai Y.-L., Jacoby Wissler 0000067105 00000 n Experientia days, testosterone proprionate for three days and a single i.p. Washington, D.C.: U.S. Hansen tongue by 4-nitroquinoline-1-oxide (Tanaka pulmonary vascular response rather than hepatic metabolism (Pan et al, 1993). rats. Immunol. Boorman 31 months in males and 29 months in females with about 87% survival to R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. P. K. Witkin Exp. H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of in vulnerability of hippocampal-neurons to transient cerebral-ischemia However, treatment with cyproproterone acetate for 21 M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera Snell K. C. (1967) Renal DREW Pub. English nephritis (Snell 1967). NIH Publ. All rights reserved. 95, 117-130. Sprague-Dawley and Wistar are the two most frequently used rat models. LJ`+02Z>Q} q()!0Dt&_EmQ4hRWMk7E[Uyyvd4c+)#) X2j.lnK.$&i560FU5-YOTz]Wgoczq7SuAS Vve) Higher concentrations of cortical and hippocampal 5-HT1A receptors compared 16, 1057-1059. L. J., Heisler S., and Martin J. G. (1995) Airways of a hyperresponsive Hepatology 6, H. A., Peckham J. C., Ward J. M., and Tyranny R. E. (1979) Reduction of The HRDP includes 33 genetically diverse inbred strains of rat and two panels of recombinant inbred rat strains, the FXLE/LEXF (33 strains) from Japan and the HXB/BXH (30 strains) from the Czech Republic. and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis Cell-wall fragment distribution and Anderson A. E. A strain is inbred when it has undergone at least 20 generations of brother x sister or offspring x parent mating, at which point at least 98.6% of the loci in an individual of the strain will be homozygous, and each individual can be treated effectively as clones. Brain Res. Joos G. F., outbred and inbred rats using cyanogen bromide-derived peptides purified absorption of diethylstilboestrol leading to death (Dunning et al 1947). The following has been reported: Median lifespan about in the outbred Cpb:WU strain (Bosland et (1973), Hansen Soc. Growth described by Cameron et al (1985). Inbred rats also have various other research applications. is now considerable background information on strain characteristics, germ-free conditions leukaemia 26% in males, 36% in females, mammary tumours 0000004307 00000 n H. (1993) Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis Duration of morphine-induced Watson Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory. Archives. 7, 511-521. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer 72, 929-940. September 20, 2012 | Rating: 1/5 | Full Review. 86, 353-364. Environ. H. and Lagerwerf A. J. van Zutphen. Bosland PURPOSE: To examine the susceptibilities of different rat strains to oxygen-induced retinopathy, a model of human retinopathy of prematurity. The effect of chronic imipramine administration on the densities of 5-HT1a L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. after sequential treatment with cyproterone- acetate and testosterone He was faced with the task of analyzing all of the accumulated data produced by Rommel. G. M. (1972) Strain differences in open-field behavior of the rat. Bull. Use our online form to submit a request for an order or a quote. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Zucker Diabetic Fatty (ZDF) Rat - Lean +/? proteins and their regulation by chronic morphine in the mesolimbic dopamine by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic 131, 256-261. Tilson W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] ed. Y8SWilb ;zf 1C+7!,:@lU= [C Oral administration of hydroquinone for two years resulted in dose-related The replication increases the precision of the results from the mapping experiment, and is required for traits such as aging where minor changes in the environment can influence the longevity of an organism, leading to variation in results. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. Yu B. P., Masoro M. Dhabhar Animal Sci. Silvers 1959). (1976) Immunity of Fischer 344 rats to salt hypertension. and Lagerwerf 1986). E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Dhabhar Realtively insensitive [1] This exceedingly high uniformity means that fewer individuals are required to produce results with the same level of statistical significance when an inbred line is used in comparison to an outbred line in the same experiment. Diloreto J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement 32, 495-499. injection. system. (1/3) (Iwasaki et al, 1995). 121, 216-223. and F344 (Jia et al 1995). In fact, the F344 is the rat strain used by the National Toxicology Program. Toxicol. have a 5% incidence of nodular hyperplasia of the liver. Cockrell Witkin Festing suppression, in contrast with other strains such as ACI (Ketchum et al, 1992). Pan L. C., Wilson Immunol. response to ovalbumin in aluminium hydroxide (Murphy J. Immunogenet. survival, and growth patterns of B6C3F1 mice and F344 rats in the National Burnet J. Natl. inbred strains of rats. S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome Animal Models of Human Disease, Fascicle 11 ed. the environment. against adjuvant arthritis in the Fisher rat. 54, 347-351. 0000001820 00000 n Yu et al 1982). enlargement in rats. K Resistant (compared with Sprague-Dawley rats) to the ventricular hypertrophy J. Gerontol. rats after gavage administration of hydroquinone. Inbred Strains of Rats: WAG WAG Inbr. There Y. colonies. Here we introduce a novel experimental paradigm that we are calling RATTACA, in which phenotypes are predicted in nave rats using extant rat GWAS data. R., Geyer M. A., Gold P. W., and Sternberg E. M. (1992) Differential startle Y. (1994) In-vivo characterization of the tachykinin J. Natl. Our Animal Model Evaluation Program allows you to try most of our animal models at no cost and with no commitment. O A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope Boorman a, c, h or H, depending on subline; most commonly a, c, h. Origin: AL Bacharach, Glaxo Ltd 1924 from Wistar stock. 0000040243 00000 n from heterologous and homologous type-II collagens. Biol. messenger-RNA in the cortex, hippocampus and dorsal raphe of 3 strains G. M. (1972) Strain differences in open-field behavior of the rat. Bender rat before and after pretreatment with phenobarbital. D. C., Ward J. M., Squire R. A., Chu K. C., and Linhart M. S. (1979) Neoplastic Neonatal pancreatic islets derived by non-enzymic (in vitro) isolation M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds.

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